Regulation of IFN-λ1 Promoter Activity (IFN-λ1/IL-29) in Human Airway Epithelial Cells

Regulation of IFN-λ1 promoter activity (IFN-λ1/IL-29) in human airway epithelial cells.

The type III (λ) IFNs (IFN-λ1, IFN-λ2, and IFN-λ3) and their receptor are the most recently discovered IFN family. They are induced by viruses and mediate antiviral activity, but type III IFNs have an important, specific functional niche at the immune/epithelial interface, as well as in the regulation of Th2 cytokines. Their expression appears diminished in bronchial epithelial cells of rhinovi...

Regulation of IFN-l1 Promoter Activity (IFN-l1/IL-29) in Human Airway Epithelial Cells

Efficacy of IFN-λ1 to Protect Human Airway Epithelial Cells against Human Rhinovirus 1B Infection

Impaired interferon (IFN) production has been observed in various obstructive respiratory diseases. This contributes to enhanced sensitivity towards viral infections triggering acute exacerbations. To compensate for this impaired host IFN response, there is need to explore new therapeutic strategies, like exogenous administration of IFNs as prophylactic treatment. In the present study, we exami...

Synergistic Up-Regulation of CXCL10 by Virus and IFN γ in Human Airway Epithelial Cells

Airway epithelial cells are the first line of defense against viral infections and are instrumental in coordinating the inflammatory response. In this study, we demonstrate the synergistic stimulation of CXCL10 mRNA and protein, a key chemokine responsible for the early immune response to viral infection, following treatment of airway epithelial cells with IFN γ and influenza virus. The synergi...

Heterologous Expression of Human IL-29 (IFN-λ1) in Iranian Lizard Leishmania

Background: Interferons with diffrent functions such as antiviral, antiproliferative and immunomodulatory actions are effctive <span style="font-varia...